Robinul for Excessive Sweating

Robinul, also known as glycopyrollate is an anticholinergic drug. Robinul blocks the action of the chemical messenger: Acetylcholine.

Acetylcholine stimulates a host of biological reactions:

It stimulates the production of sweat and saliva, it slows down the heart, it stimulates the intestines, and is responsible for neuromuscular transmission.

Blocking the action of Acetylcholine by administrating Robinul will certainly inhibit the production of sweat, thus managing the hyperhidrosis, but it will also cause various side effects such as a loss of taste, dry mouth, constipation, blurred vision, dry eyes, urinary retention, palpitations and dizziness.

In the case of secondary hyperhidrosis, it’s logical to tackle the cause of the excessive sweating and not just treat the symptom.

In the case of primary hyperhidrosis, Robinul can be prescribed.

Robinul can be administered topically in the form of creams, gels and lotions as well as systemically, in the form of oral medication.

A number of studies have concluded positive results from Robinul application. The side-effects tend to be less significant than with taking Robinul tablets.

Oral Robinul is best-suited for patients with certain types of hyperhidrosis such as excessive facial sweating, generalized hyperhidrosis or patients who have not had success using other treatment options such as high-strength antiperspirants, botox, iontophoresis, or a combination of these.

It’s important to mention that oral Robinul has not been cleared by the FDA as a specific treatment for hyperhidrosis. But since its anti-sweating properties are well documented, it is commonly prescribed without FDA approval, off label.

To conclude, excessive sweating can be a serious issue that messes with a patient’s quality of life. To manage hyperhidrosis, it’s best to start with antiperspirants.

If they don’t work; the patient can visit a doctor to determine which type of hyperhidrosis they have and which medication is best to tackle the problem.

If taking anticholinergics like Robinul, it’s important to keep mindful of the side effects and to notify your doctor of any weird symptoms or sensations.

Dr. Gary C. Anderson M.D is a Surgeon who specializes in the treatment of hyperhidrosis. During the past 20 years, he has performed over 2000 sympathectomy procedures on patients with sweating of the underarms, hands, face, scalp or blushing.